US Patent Issued to THE CLEVELAND CLINIC FOUNDATION on Sept. 22 for "Small molecule nicotinamide adenine dinucleotide modulators" (Ohio Inventors)

ALEXANDRIA, Va., Sept. 24 -- United States Patent no. 12,741,933, issued on Sept. 22, was assigned to THE CLEVELAND CLINIC FOUNDATION (Cleveland).

"Small molecule nicotinamide adenine dinucleotide modulators" was invented by Babal Kant Jha (Cleveland), James G. Phillips (Cleveland), Jaroslaw P. Maciejewski (Cleveland) and Frederic Joel Reu (Cleveland).

According to the abstract* released by the U.S. Patent & Trademark Office: "Compounds that can be used to increase NAD levels are described by inhibiting NAD+ degrading enzymes such as CD38 are described. The compounds have a structure according to formula I or Formula II, as described herein, or pharmaceutically acceptable salts thereof, wherein the attached groups are as defined in the sp...