US Patent Issued to The Cleveland Clinic Foundation on March 17 for "Disease detection and treatment based on trimethyl-lysine levels" (Ohio Inventors)

ALEXANDRIA, Va., March 17 -- United States Patent no. 12,576,055, issued on March 17, was assigned to The Cleveland Clinic Foundation (Cleveland).

"Disease detection and treatment based on trimethyl-lysine levels" was invented by Stanley L. Hazen (Pepper Pike, Ohio), Zeneng Wang (Shaker Heights, Ohio) and Xinmin S. Li (Cleveland).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to systems, kits, and methods for identifying subjects with increased levels of N6-trimethyl-lysine (TML) or the combination of TML and trimethylamine-n-oxide (TMAO), as well as methods of determining risk of disease (e.g., kidney disease or heart failure) based on such levels. In certain embodiments, subjec...