US Patent Issued to THE CLEVELAND CLINIC FOUNDATION on June 9 for "Bioavailable protein disulfide isomerase inhibitors" (Ohio Inventors)

ALEXANDRIA, Va., June 9 -- United States Patent no. 12,649,734, issued on June 9, was assigned to THE CLEVELAND CLINIC FOUNDATION (Cleveland).

"Bioavailable protein disulfide isomerase inhibitors" was invented by Babal K. Jha (Cleveland), James G. Phillips (Cleveland), Frederic J. Reu (Cleveland), Metis Hasipek (Cleveland), Dale Grabowski (Cleveland) and Jaroslaw P. Maciejewski (Cleveland).

According to the abstract* released by the U.S. Patent & Trademark Office: "Compounds according to formula (I) are described wherein R1 is an amino acid or a modified amino acid linked to the compound through a peptide bond, R2 is selected from CN, SO2CH3, NO2, CO2R3, CONHR3, NH2, NMe2 and CF3, and R3 is selected from H or lower alkyl, X is O or S, and...