US Patent Issued to The Children's Hospital of Philadelphia on Sept. 8 for "Net stabilization as a therapy for sepsis" (Pennsylvania Inventors)

ALEXANDRIA, Va., Sept. 8 -- United States Patent no. 12,728,153, issued on Sept. 8, was assigned to The Children's Hospital of Philadelphia (Philadelphia).

"Net stabilization as a therapy for sepsis" was invented by Mortimer Poncz (Philadelphia), Kandace Gollomp (Philadelphia), Lubica Rauvo (Philadelphia) and Anna M. Kowalska (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure is directed to the use of PF4 alone or anti-PF4 antibodies alone or the combination thereof to treat sepsis. Neutrophils release their histone-coated DNA termed neutrophil extracellular traps (NETs) during sepsis and related inflammatory disorders. NETs are broken down and release NET degradation product...