US Patent Issued to The Broad Institute, President and Fellows of Harvard College on Sept. 29 for "AAV delivery of nucleobase editors" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 30 -- United States Patent no. 12,746,294, issued on Sept. 29, was assigned to The Broad Institute Inc. (Cambridge, Mass.) and President and Fellows of Harvard College (Cambridge, Mass.).

"AAV delivery of nucleobase editors" was invented by David R. Liu (Cambridge, Mass.), Jonathan Ma Levy (Cambridge, Mass.) and Wei Hsi Yeh (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are methods of delivering "split" Cas9 protein or nucleobase editors into a cell, e.g., via a recombinant adeno-associated vims (rAAV), to form a complete and functional Cas9 protein or nucleobase editor. The Cas9 protein or the nucleobase editor is split into two sections, each fused w...