US Patent Issued to THE BROAD INSTITUTE, Massachusetts Institute of Technology, PRESIDENT AND FELLOWS OF HARVARD COLLEGE on Feb. 17 for "Optimized CRISPR-CAS double nickase systems, methods and compositions for sequence manipulation" (Massachusetts Inventors)

ALEXANDRIA, Va., Feb. 17 -- United States Patent no. 12,553,065, issued on Feb. 17, was assigned to THE BROAD INSTITUTE INC. (Cambridge, Mass.), Massachusetts Institute of Technology (Cambridge, Mass.) and PRESIDENT AND FELLOWS OF HARVARD COLLEGE (Cambridge, Mass.).

"Optimized CRISPR-CAS double nickase systems, methods and compositions for sequence manipulation" was invented by Feng Zhang (Cambridge, Mass.), Patrick Hsu (Cambridge, Mass.), Chie-yu Lin (Cambridge, Mass.) and Fei Ran (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target seq...