US Patent Issued to The Brigham and Women's Hospital on June 30 for "KLRB1 binding agents and methods of use thereof" (Massachusetts Inventor)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,668,637, issued on June 30, was assigned to The Brigham and Women's Hospital Inc. (Boston).

"KLRB1 binding agents and methods of use thereof" was invented by Steven A. Greenberg (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "KLRB1 binding agents (in particular anti-KLRB1-antibodies and antigen binding portion thereof) with increased humanness and compositions thereof, as well as therapeutic methods of using the agents, e.g., for depleting cells or inhibiting cells or activating cells, (in particular, Th17, Th17.1, ex-Th17, Tc17, MAIT, iNKT, peTh2, ILC2, ILC3, NK cells, and/or neoplastic T or NK cells in vivo), for the treatment of autoimmune dis...