US Patent Issued to The Board of Trustees of the Leland Stanford Junior University on Nov. 3 for "Chemically reversible 2'-OH acylation protects RNA from hydrolytic and enzymatic degradation" (California Inventors)

ALEXANDRIA, Va., Nov. 3 -- United States Patent no. 12,781,220, issued on Nov. 3, was assigned to The Board of Trustees of the Leland Stanford Junior University (Stanford, Calif.).

"Chemically reversible 2'-OH acylation protects RNA from hydrolytic and enzymatic degradation" was invented by Linglan Fang (Stanford, Calif.) and Eric T. Kool (Stanford, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Compositions and methods are provided for the reversible modification of RNA to enhance RNA in-solution and enzymatic stability by reaction with acylimidazoles, sulfonyltriazoles, or sulfonylimidazoles. 2'-OH acylation protects RNA from hydrolytic and enzymatic degradation. Water-soluble organocatalysts can ac...