ALEXANDRIA, Va., April 21 -- United States Patent no. 12,605,458, issued on April 21, was assigned to SYSTIMMUNE INC. (Redmond, Wash.).
"Antibody-drug conjugate having acidic self-stabilization junction" was invented by Yi Zhu (Chengdu, China), Yiqian Wang (Chengdu, China), Jie Li (Chengdu, China), Shi Zhuo (Chengdu, China) and Weili Wan (Chengdu, China).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a special drug conjugate having a hydrophilic acidic stabilization junction. Compared with a conjugate having a lower drug loading, due to the introduction of the acidic stabilization junction, the conjugate in the present invention can also have a higher drug loading (that is, each...