US Patent Issued to ST. JUDE CHILDREN'S RESEARCH HOSPITAL on June 2 for "Chimeric GMCSF-IL18 receptor" (Dutch, American Inventors)

ALEXANDRIA, Va., June 2 -- United States Patent no. 12,643,936, issued on June 2, was assigned to ST. JUDE CHILDREN'S RESEARCH HOSPITAL INC. (Memphis, Tenn.).

"Chimeric GMCSF-IL18 receptor" was invented by Stephen Gottschalk (Germantown, Tenn.), Laurens Sand (Utrecht, Netherlands) and Shannon Lange (Memphis, Tenn.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides chimeric cytokine receptors, particularly chimeric cytokine receptors that can be activated in tumor microenvironment, and their uses in tumor immunotherapy (e.g., adoptive cell therapy). The present invention further provides methods of genetically modifying therapeutic cells resulting in an enhanced immune response agai...