ALEXANDRIA, Va., Sept. 24 -- United States Patent no. 12,741,972, issued on Sept. 22, was assigned to SOOCHOW UNIVERSITY (Suzhou, China).

"Method for carrying out reaction of isatin compound and cyclopropenone compound at low catalytic amount" was invented by Fan Xu (Suzhou, China), Qifa Chen (Suzhou, China), Yue Teng (Suzhou, China) and Zhigang Yao (Suzhou, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method for the reaction of an isatin and cyclopropenone compound at low catalytic amount. In the presence of an amine compound and phosphite, the isatin and cyclopropenone are reacted in an organic solvent using a silicon amino rare earth compound as a catalyst to synthesize pyrano[2,3-b]indol-2-one ...