ALEXANDRIA, Va., March 24 -- United States Patent no. 12,582,842, issued on March 24, was assigned to SIEMENS HEALTHINEERS INTERNATIONAL AG (Switzerland).

"Treatment adaptation in radiotherapy based on intra-fraction dosing" was invented by Amir Talakoub (Marblehead, Mass.) and Stefan Thieme-Marti (Windisch, Switzerland).

According to the abstract* released by the U.S. Patent & Trademark Office: "A computer-implemented method of radiotherapy within a region of patient anatomy includes: determining a first radiation dose that is delivered during a first time segment of a treatment fraction to a first location, wherein the first radiation dose is based on a first machine state of a radiotherapy system associated with the first time segment;...