ALEXANDRIA, Va., July 21 -- United States Patent no. 12,686,703, issued on July 21, was assigned to Sederma (Le Perray-en-Yvelines, France).

"Cosmetic tetrapeptide, composition and use" was invented by Philippe Mondon (Montrouge, France), Olivier Peschard (Rambouillet, France) and Richard Leroux (Faverolles, France).

According to the abstract* released by the U.S. Patent & Trademark Office: "The tetrapeptide has the general Formula X-LLAN-Z (SEQ ID NO: 6) wherein at the N-terminal end X is selected from H, -CO-R1, -SO2-R1 or a biotinoyl group, at the C-terminal end Z is selected from OH, OR1, NH2, NHR1 or NR1R2, and R1 and R2 are selected from an alkyl, aryl, aralkyl, alkylaryl, alkoxy, saccharide and aryloxy, said group having from 1 to ...