US Patent Issued to Seattle Children's Hospital on Aug. 11 for "Methods and compositions for engineering CD4-deficient CAR T cells and anti-CD4 CAR T cells and uses thereof" (Washington Inventors)

ALEXANDRIA, Va., Aug. 12 -- United States Patent no. 12,703,735, issued on Aug. 11, was assigned to Seattle Children's Hospital (Seattle).

"Methods and compositions for engineering CD4-deficient CAR T cells and anti-CD4 CAR T cells and uses thereof" was invented by Thor Wagner (Seattle) and Jaya Sahni (Seattle).

According to the abstract* released by the U.S. Patent & Trademark Office: "Some aspects of the methods and compositions provided herein relate to the disruption of at least one CD4 gene in a cell, such as a CD4+ T cell. In some embodiments, the disruption comprises use of a CRISPR guide polynucleotide. Some embodiments also include the preparation and use of a cell having at least one disrupted CD4 gene and a chimeric antigen rec...