US Patent Issued to Scancell on April 7 for "Modified Fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof" (British Inventors)

ALEXANDRIA, Va., April 7 -- United States Patent no. 12,595,313, issued on April 7, was assigned to Scancell Ltd. (Oxford, Great Britain).

"Modified Fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof" was invented by Linda Gillian Durrant (Nottingham, Great Britain) and Mireille Vankemmelbeke (Nottingham, Great Britain).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to the identification of key residues within mouse IgG3 antibodies (mAbs) that are responsible for intermolecular cooperativity and their transfer into IgG1 antibodies in order to enhance their functional affinity and direct a cell killing."

The patent was filed on July 31, ...