US Patent Issued to Saint Louis University on March 31 for "Reprogramming of lipid metabolism to inhibit T cell senescence and enhance tumor immunotherapy" (Missouri Inventors)

ALEXANDRIA, Va., March 31 -- United States Patent no. 12,590,309, issued on March 31, was assigned to Saint Louis University (St. Louis).

"Reprogramming of lipid metabolism to inhibit T cell senescence and enhance tumor immunotherapy" was invented by Guangyong Peng (St. Louis) and Xia Liu (St. Louis).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides compositions and methods for inhibiting T cell senescence and improving T cell immunotherapies. In particular, inhibitors of group IV A phospholipase A2 are disclosed as useful in modulating the lipid metabolism of cells, in particular effector T cells, such that T reg- and tumor cell-induced cell senescence is abrogated. These methods...