US Patent Issued to RUIJIN HOSPITAL SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE on April 21 for "High-activity blood coagulation factor XI mutant Ala570Thr" (Chinese Inventors)

ALEXANDRIA, Va., April 21 -- United States Patent no. 12,605,430, issued on April 21, was assigned to RUIJIN HOSPITAL SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE (Shanghai).

"High-activity blood coagulation factor XI mutant Ala570Thr" was invented by Wenman Wu (Shanghai), Xuefeng Wang (Shanghai) and Qiulan Ding (Shanghai).

According to the abstract* released by the U.S. Patent & Trademark Office: "A high-activity blood coagulation factor XI mutant Ala570Thr (A570T), having nucleotide sequences as shown in SEQ ID NOs: 1-4 and an amino acid sequence as shown in SEQ ID NO: 5, is provided. The mutant is resistant to a physiological inhibitor thereof after being activated from a zymogen state to an active enzyme. Therefore, the mutant has ...