US Patent Issued to RIKEN, UNIVERSITY OF TSUKUBA on Feb. 24 for "Mutant KLF protein, and method for producing induced pluripotent stem cells" (Japanese Inventors)

ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,730, issued on Feb. 24, was assigned to RIKEN (Wako, Japan) and UNIVERSITY OF TSUKUBA (Tsukuba, Japan).

"Mutant KLF protein, and method for producing induced pluripotent stem cells" was invented by Yohei Hayashi (Wako, Japan), Evgeniia Borisova (Wako, Japan), Koji Hisatake (Tsukuba, Japan), Ken Nishimura (Tsukuba, Japan) and Fumiaki Yumoto (Tsukuba, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "There is provided a mutant KLF protein that can induce reprogramming of a somatic cell at a higher efficiency than a KLF protein having a natural amino acid sequence. There is also provided a method for efficiently producing an iPS cell by using the mu...