US Patent Issued to RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL on Sept. 8 for "Transforming growth factor beta-resistant natural killer cells" (Ohio, Missouri Inventors)

ALEXANDRIA, Va., Sept. 8 -- United States Patent no. 12,729,228, issued on Sept. 8, was assigned to RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (Columbus, Ohio).

"Transforming growth factor beta-resistant natural killer cells" was invented by Dean Anthony Lee (Canal Winchester, Ohio), Jennifer Ann Foltz-Stringfellow (St. Louis) and Jena Edwards-Moseman (Columbus, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "An NK cell with low SMAD3 expression and altered gene expression profile resulting in high cytokine expression and TGF-Beta superfamily resistance is described, refered to herein as TGF-Beta superfamily-imprinted Natural Killer Cells (TGFBetai NK cells). A method of treating cancer or infe...