US Patent Issued to Regents of the University of Minnesota, Regents of the University of California on April 21 for "Compounds that degrade kinases and uses thereof" (Minnesota, California Inventors)

ALEXANDRIA, Va., April 21 -- United States Patent no. 12,605,452, issued on April 21, was assigned to Regents of the University of Minnesota (Minneapolis) and Regents of the University of California (Oakland, Calif.).

"Compounds that degrade kinases and uses thereof" was invented by Daniel A. Harki (Minneapolis), Jian Tang (Minneapolis), Ramkumar Moorthy (Bloomington, Minn.), Rommie E. Amaro (San Diego) and Ozlem Demir (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure is directed to compounds of the Formula (I) or (II): A-L1-B, A'-L1-B, or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein A is an Aurora A ligand, A' is a CDK4/6 ligand; B is a...