ALEXANDRIA, Va., June 9 -- United States Patent no. 12,649,764, issued on June 9, was assigned to REGENERON PHARMACEUTICALS INC. (Tarrytown, N.Y.).
"Method for viral inactivation" was invented by John Mattila (Nyack, N.Y.), Andrew Barmasse (Tarrytown, N.Y.) and Mark Chiboroski (Ossining, N.Y.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Embodiments of the present disclosure are directed to systems and methods for modulating pH in a mixture containing a polypeptide. The pH may be modulated for any suitable purpose, e.g., inactivating virus in the mixture. Methods may include eluting, from a chromatography column, a mixture (e.g., an eluate) having a pH greater than, e.g., 3.9 and less than, e.g., 8.5. Metho...