US Patent Issued to Purdue Research Foundation on May 12 for "Rejuvenation of CAR T cell" (Indiana Inventors)

ALEXANDRIA, Va., May 12 -- United States Patent no. 12,622,973, issued on May 12, was assigned to Purdue Research Foundation (West Lafayette, Ind.).

"Rejuvenation of CAR T cell" was invented by Philip Stewart Low (West Lafayette, Ind.), Boning Zhang (West Lafayette, Ind.) and John V. Napoleon (West Lafayette, Ind.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A payload of drug conjugated to a targeting ligand specifically designed to deliver to exhausted CAR T cells to rejuvenate these CAR T cells is provided herein. The targeted CAR T cells are modified with a fusion receptor which can bind to the targeting ligand internalize the conjugated payload of drug to execute its regulatory function to exhausted CA...