ALEXANDRIA, Va., July 7 -- United States Patent no. 12,674,146, issued on July 7, was assigned to Protalix Ltd. (Carmiel, Israel).
"Modified uricase and uses thereof" was invented by Ilya Ruderfer (Carmiel, Israel), Yakir Nataf (Kiryat Motzkin, Israel), Gil Arvatz (Kfar Tavor, Israel), Uri Hanania (Carmiel, Israel), Tamar Ariel (Manof, Israel), Shelly Rozen (Yuvalim, Israel) and Yael Hayon (Tel Aviv, Israel).
According to the abstract* released by the U.S. Patent & Trademark Office: "A modified uricase is described herein, as well as a method of reducing a level of uric acid by contacting a medium with the modified uricase. The modified uricase comprises a uricase polypeptide crosslinked by at least one bifunctional linking moiety that co...