US Patent Issued to Precision BioSciences on Oct. 6 for "Engineered meganucleases having specificity for a recognition sequence in the hydroxyacid oxidase 1 gene" (North Carolina Inventors)

ALEXANDRIA, Va., Oct. 6 -- United States Patent no. 12,752,019, issued on Oct. 6, was assigned to Precision BioSciences Inc. (Durham, N.C.).

"Engineered meganucleases having specificity for a recognition sequence in the hydroxyacid oxidase 1 gene" was invented by James Jefferson Smith (Morrisville, N.C.), Janel Lape (Wake Forest, N.C.) and John Morris (Raleigh, N.C.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are engineered meganucleases that bind and cleave a recognition sequence within a hydroxyacid oxidase 1 (HAO1) gene. The present invention also encompasses methods of using such engineered meganucleases to make genetically-modified cells. Further, the invention encompasses pharmaceutical co...