ALEXANDRIA, Va., March 31 -- United States Patent no. 12,590,080, issued on March 31, was assigned to PAKINAX PTY LTD. (Victoria, Australia).
"Compounds" was invented by Jun Zeng (Victoria, Australia), Mehrdad Nikfarjam (Victoria, Australia) and Hong He (Victoria, Australia).
According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are compounds that are inhibitors of p21-activated kinases (PAKS). In particular, the compounds described herein are demonstrated to be selective PAK4 inhibitors. The compounds described herein are also demonstrated to reduce the expression of key immune checkpoint molecules, such as PD-1 and CHEK2. Also described herein are pharmaceutical compositions containing such compoun...