ALEXANDRIA, Va., April 21 -- United States Patent no. 12,605,425, issued on April 21, was assigned to OXFORD UNIVERSITY INNOVATION Ltd. (Oxford, Great Britain).
"TNF muteins and uses thereof" was invented by Nicola R. Sibson (Oxford, Great Britain), Daniel C. Anthony (Oxford, Great Britain) and Sandra J. Campbell (Oxford, Great Britain).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to tumour necrosis factor (TNF) muteins with improved properties, and in particular to TNF muteins which are agonists of, and bind selectively to, tumour necrosis factor receptor 1 (TNFR1). Compositions comprising the TNF muteins, which may additionally comprise appropriate anticancer agents or imagin...