US Patent Issued to OTSUKA PHARMACEUTICAL on Jan. 20 for "Method for producing centanafadine" (Japanese Inventors)

ALEXANDRIA, Va., Jan. 20 -- United States Patent no. 12,528,771, issued on Jan. 20, was assigned to OTSUKA PHARMACEUTICAL Co. LTD. (Tokyo).

"Method for producing centanafadine" was invented by Rei Otsuka (Osaka, Japan), Kimiyoshi Annaka (Osaka, Japan) and Hikaru Mitani (Osaka, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention addresses the problem of finding a method for reliably producing (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride, wherein crystalline polymorphs can be controlled with industrially easy operations. Provided is a method for producing a crystalline form of (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane hydrochloride, the method comprisin...