US Patent Issued to OSPEDALE PEDIATRICO BAMBINO GESU' on Aug. 4 for "CAR-CD123 vector and uses thereof" (Italian Inventors)

ALEXANDRIA, Va., Aug. 5 -- United States Patent no. 12,698,333, issued on Aug. 4, was assigned to OSPEDALE PEDIATRICO BAMBINO GESU' (Rome).

"CAR-CD123 vector and uses thereof" was invented by Concetta Quintarelli (Rome), Biagio De Angelis (Rome) and Franco Locatelli (Rome).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a chimeric antigen receptor (CAR) molecule containing, from the N-terminus to the C-terminus: a) an extracellular domain and transmembrane domain of human CD19, b) an antigen binding domain, c) a spacer domain, d) a transmembrane domain, and e) a cytoplasmatic domain, preferably wherein the CAR is a CD123 specific CAR (CD123 CAR) and the antigen binding domain i...