ALEXANDRIA, Va., June 9 -- United States Patent no. 12,649,784, issued on June 9, was assigned to Oregon Health & Science University (Portland, Ore.).
"Monoclonal antibodies for intracellular delivery of payloads" was invented by John L. Muschler (Lake Oswego, Ore.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to delivering payloads to the interior of a cell. In particular, the present disclosure provides three monoclonal antibodies that bind dystroglycan (DG) on the surface of cells. The antibodies are internalized into endocytic vesicles inside the cells once they are bound to DG. Thus, these antibodies can be used to selectively target and deliver payloads to cells, such as...