ALEXANDRIA, Va., May 12 -- United States Patent no. 12,624,068, issued on May 12, was assigned to OliPass Corp. (Yongin-si, South Korea).
"Exon skipping by peptide nucleic acid derivatives" was invented by Shin Chung (Yongin-si, South Korea), Daram Jung (Hwaseong-Si, South Korea), Bongjun Cho (Yongin-Si, South Korea), Kangwon Jang (Yongin-Si, South Korea) and Heungsik Yoon (Seongnam-Si, South Korea).
According to the abstract* released by the U.S. Patent & Trademark Office: "A peptide nucleic acid derivative of Formula I is provided to tightly bind to a splice site within a pre-mRNA in a sequence specific manner. Given with excellent cell membrane permeability and strong affinity for RNA, the peptide nucleic acid derivative induces exon s...