ALEXANDRIA, Va., April 15 -- United States Patent no. 12,600,769, issued on April 14, was assigned to Novartis AG (Basel, Switzerland).
"Stable and soluble antibodies inhibiting VEGF" was invented by Leonardo Borras (Schlieren, Switzerland), David Urech (Hombrechtikon, Switzerland) and Tea Gunde (Zurich).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to soluble and stable anti-VEGF imunobinders comprising CDRs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and...