US Patent Issued to NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS on July 28 for "Methods of treatment of cancer with antibody-IL-2 engrafted proteins" (California Inventors)

ALEXANDRIA, Va., July 28 -- United States Patent no. 12,691,181, issued on July 28, was assigned to NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS INC. (San Diego).

"Methods of treatment of cancer with antibody-IL-2 engrafted proteins" was invented by Jonathan Deane (San Diego), Yaiza Diaz-De-Durana (San Diego), Michael Didonato (San Diego), Christophe Filippi (San Diego) and Glen Spraggon (San Diego).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides for IL2 engrafted into the CDR sequences of an antibody having preferred therapeutic profiles over molecules known and used in the clinic. In particular, the provided antibody cytokine engrafted protein compositions increase or maintain C...