ALEXANDRIA, Va., March 3 -- United States Patent no. 12,564,639, issued on March 3, was assigned to Northeastern University (Boston).

"Cationic nanostructures for intra-cartilage delivery of contrast agents and diagnostic uses thereof" was invented by Ambika Bajpayee (Cambridge, Mass.), Chenzhen Zhang (Boston), Armin Vedadghavami (Boston) and Tengfei He (Malden, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a platform for the delivery of small molecule drugs or contrast agents to joints and other soft tissues. The platform enables penetration of the drug through the full thickness of cartilage and long intra-cartilage residence time by leveraging electrostatic interactio...