US Patent Issued to Navidea Biopharmaceuticals on March 24 for "Synthesis of uniformly defined molecular weight mannosylated dextrans and derivatives thereof" (Massachusetts, Ohio Inventors)

ALEXANDRIA, Va., March 24 -- United States Patent no. 12,583,945, issued on March 24, was assigned to Navidea Biopharmaceuticals Inc. (Columbus, Ohio).

"Synthesis of uniformly defined molecular weight mannosylated dextrans and derivatives thereof" was invented by Jeffrey Arnold (Andover, Mass.) and David A. Ralph (Columbus, Ohio).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein is method for conjugating a metal chelating agent to a functionalized dextran by reacting a chelator with an aminated dextran backbone, where the chelator comprises a one, and only one, derivatized carboxylic acid group to form a chelator-dextran complex. In certain aspects, the dextran-chelator complex is substantially ...