US Patent Issued to NATIONAL HEALTH RESEARCH INSTITUTES on Feb. 24 for "Use of succinate as biomarker in diagnosis and treatment of cancers" (Taiwanese Inventors)

ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,574, issued on Feb. 24, was assigned to NATIONAL HEALTH RESEARCH INSTITUTES (Miaoli County, Taiwan).

"Use of succinate as biomarker in diagnosis and treatment of cancers" was invented by Cheng-Chin Kuo (Miaoli County, Taiwan) and Jing-Yiing Wu (Miaoli County, Taiwan).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention discloses that cancer cells secrete succinate into extracellular milieu, which increases macrophage migration and mediates TAM polarization. Furthermore, succinate induces cancer cell EMT, enhances cancer cell migration, and promotes cancer metastasis in murine models. It is indicated in the present invention that serum...