ALEXANDRIA, Va., Sept. 15 -- United States Patent no. 12,735,450, issued on Sept. 15, was assigned to Miltenyi Biotec B.V. & Co. KG (Bergisch Gladbach, Germany).

"Serum resistant bis-sulfhydryl specific biotinylation reagent" was invented by Jonathan Fauerbach (Bergisch Gladbach, Germany), Tina Borke (Bergisch Gladbach, Germany), Jorg Mittelstaet (Bergisch Gladbach, Germany) and Sandra Dapa (Bergisch Gladbach, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "Biotinylation reagent has a structure according to formula (I) With R1=alkyl, hydroxyalkyl or carboxyalkyl residue comprising 1 to 50 carbon atoms R2=alkyl, glycol, amine or peptide reside with 1 to 50 carbon atoms R3=Aryl, heteroaryl, with 3 to 50...