US Patent Issued to Miltenyi Biotec on June 30 for "Gene specific spatial rolling circle amplification and NGS sequencing" (German Inventors)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,668,838, issued on June 30, was assigned to Miltenyi Biotec B.V. & Co. KG (Bergisch Gladbach, Germany).

"Gene specific spatial rolling circle amplification and NGS sequencing" was invented by Robert Pinard (Bergisch Gladbach, Germany) and Seiyu Hosono (Bergisch Gladbach, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention is directed to a method to simultaneously obtain both the spatial location and sequence information of a target sequence with a higher resolution than the known technologies. The method comprises steps to spatially localize the mRNA expressed on a tissue by the use of a hybrid circular/linear DNA probe with a UMI and, ...