ALEXANDRIA, Va., May 12 -- United States Patent no. 12,624,351, issued on May 12, was assigned to MICROSOFT TECHNOLOGY LICENSING LLC (Redmond, Wash.).
"Real-time detection of errors in oligonucleotide synthesis" was invented by Bichlien Hoang Nguyen (Seattle), Jake Smith (Seattle), Karin Strauss (Seattle) and Robert Carlson (Seattle).
According to the abstract* released by the U.S. Patent & Trademark Office: "Fluorophores are used during the synthesis of oligonucleotides to achieve real-time quality control of the synthesis process. Fluorescence may indicate successful addition of individual nucleotides to a growing oligonucleotide strand or removal of a blocking group. The oligonucleotides may be created by enzymatic synthesis using term...