ALEXANDRIA, Va., March 24 -- United States Patent no. 12,583,871, issued on March 24, was assigned to Merck Sharp & Dohme LLC (Rahway, N.J.).
"PRMT5 inhibitors" was invented by Michelle Machacek (Boston), Michael D. Altman (Boston), Shuhei Kawamura (Boston), David L Sloman (Boston), David J. Witter (Toronto) and Craig R. Gibeau (Boston).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a compound selected from: and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds disclosed herein, pharmaceutical compositions comprising compounds disclosed herein, and methods of using these compounds to tre...