US Patent Issued to MERCK SHARP & DOHME on March 17 for "PCSK9 antagonist compounds" (New Jersey, Pennsylvania Inventors)

ALEXANDRIA, Va., March 17 -- United States Patent no. 12,577,259, issued on March 17, was assigned to MERCK SHARP & DOHME LLC (Rahway, N.J.).

"PCSK9 antagonist compounds" was invented by Hubert Josien (Jersey City, N.J.), Jian Liu (Edison, N.J.), Thomas Joseph Tucker (North Wales, Pa.), Abbas M. Walji (Lansdale, Pa.) and Harold B. Wood (Westfield, N.J.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof: (I) wherein A, A1, A2, R1, R2 and R3 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods...