US Patent Issued to Merck Sharp & Dohme on Feb. 24 for "Tetrahydroquinazoline derivatives as selective cytotoxic agents" (Pennsylvania, New York Inventors)

ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,558,357, issued on Feb. 24, was assigned to Merck Sharp & Dohme LLC (Rahway, N.J.).

"Tetrahydroquinazoline derivatives as selective cytotoxic agents" was invented by Antonella Converso (Elkins Park, Pa.), Abdellatif El Marrouni (Ambler, Pa.), Anthony W. Shaw (Harleysville, Pa.), David N. Hunter (Hatfield, Pa.), Ashley Forster (Gilbertsville, Pa.), Cheng Wang (Fort Washington, Pa.) and Yunlong Zhang (Valhalla, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure is directed to tetrahydroquinazoline derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to...