US Patent Issued to MeiraGTx Gene Regulation on Feb. 24 for "Regulation of gene expression through aptamer-modulated polyadenylation" (New York, Massachusetts Inventors)

ALEXANDRIA, Va., Feb. 24 -- United States Patent no. 12,559,757, issued on Feb. 24, was assigned to MeiraGTx Gene Regulation Ltd. (London).

"Regulation of gene expression through aptamer-modulated polyadenylation" was invented by Michael J. Volles (Cambridge, Mass.), Olivier F. Danos (New York) and Xuecui Guo (Oyster Bay, N.Y.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides polynucleotide constructs for the regulation of gene expression by aptamer-based modulation of U1 snRNP-mediated suppression of polyadenylation and methods of using the constructs to regulate gene expression in response to the presence or absence of a ligand that binds the aptamer. The polynucleotide construct contai...