US Patent Issued to Massachusetts Institute of Technology on Dec. 30 for "Circular RNA for translation in eukaryotic cells" (American, Irish Inventors)

ALEXANDRIA, Va., Dec. 31 -- United States Patent no. 12,509,701, issued on Dec. 30, was assigned to Massachusetts Institute of Technology (Cambridge, Mass.).

"Circular RNA for translation in eukaryotic cells" was invented by Daniel G. Anderson (Framingham, Mass.), Robert Alexander Wesselhoeft (Boston) and Piotr S. Kowalski (Cork, Ireland).

According to the abstract* released by the U.S. Patent & Trademark Office: "Circular RNA and methods and constructs for engineering circular RNA are disclosed. In some embodiments, the circular RNA includes the following elements arranged in the following sequence: a) a 3' Group I self-splicing intron fragment, b) an internal ribosome entry site (IRES), c) a protein coding region or noncoding region, an...