ALEXANDRIA, Va., June 2 -- United States Patent no. 12,643,912, issued on June 2, was assigned to LES LABORATOIRES SERVIER (Suresnes Cedex, France).

"Macrocyclic compounds, a process for their preparation and pharmaceutical compositions containing them" was invented by Csaba Weber (Pilisszentlaszlo, Hungary), Klaus Seedorf (Hamburg, Germany), Didier Durand (Chambourcy, France), Mario Gyuris (Szeged, Hungary), Arpad Kiss (Budakalasz, Hungary), Zoltan Madarasz (Budapest, Hungary), Mark Molnar (Val, Hungary), Miklos Nyerges (Leanyfalu, Hungary), Monika Rudasova (Budapest, Hungary), Attila Sapi (Hevizgyork, Hungary), Sylvie Berger (Nanterre, France), Valerie Duvivier (Orsay, France), Virginie Martiny (Montgeron, France), Isabelle Theret (Monte...