US Patent Issued to KSQ Therapeutics on March 31 for "NR4A super-repressors and methods of use thereof" (Massachusetts Inventors)

ALEXANDRIA, Va., March 31 -- United States Patent no. 12,590,312, issued on March 31, was assigned to KSQ Therapeutics Inc. (Cambridge, Mass.).

"NR4A super-repressors and methods of use thereof" was invented by Michael Schlabach (Belmont, Mass.) and Brian Alexander Sosa-Alvarado (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides super-repressors capable of inhibiting the transcription of NR4A1, NR4A2, and NR4A3 target genes. The super-repressors can be used to enhance the effector functions of immune cells, e.g., for adoptive cell therapy. Methods of treating disorders using the modified immune cells are also provided."

The patent was filed on May 21, 2020, unde...