US Patent Issued to King's College London on July 14 for "AAV vector for neuronal expression of progranulin" (British Inventors)

ALEXANDRIA, Va., July 14 -- United States Patent no. 12,680,109, issued on July 14, was assigned to King's College London (London).

"AAV vector for neuronal expression of progranulin" was invented by Christopher Edward Dennistoun Shaw (London) and Youn Bok Lee (London).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to the field of recombinant viral vectors suitable for the delivery of therapeutic genes in vivo. Described is an adeno-associated virus (AAV) vector comprising (i) a human growth hormone intron 3 (hGHi3) sequence (ii) a synapsin promoter sequence and/or (iii) a progranulin 3' untranslated region (UTR) sequence, operably coupled to a polynucleotide sequence encoding a ...