ALEXANDRIA, Va., March 31 -- United States Patent no. 12,589,110, issued on March 31, was assigned to KAO Corp. (Tokyo).

"Carbonated aerosol external preparation for skin" was invented by Ryoko Harada (Funabashi, Japan), Tadashi Miyazaki (Sumida-ku, Japan) and Megumi Matsuoka (Katsushika-ku, Japan).

According to the abstract* released by the U.S. Patent & Trademark Office: "A carbonated aerosol external preparation for skin, including a stock solution containing the following components (A) to (C), and a propellant containing the following component (D): (A) heparinoid, (B) water-soluble polymer, (C) water, and (D) carbon dioxide gas. The carbonated aerosol external preparation for skin has a pH immediately after discharge of 4.0 or more ...