ALEXANDRIA, Va., Sept. 15 -- United States Patent no. 12,735,449, issued on Sept. 15, was assigned to JIANGXI NORMAL UNIVERSITY (Nanchang, China).

"Alpha-carbonyl alkenyl ester preparation method therefor and application thereof" was invented by Junfeng Zhao (Nanchang, China), Zhengning Wang (Nanchang, China) and Xuewei Wang (Nanchang, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "There is provided an Alpha-carbonyl alkenyl ester and a preparation method therefor, and the Alpha-carbonyl alkenyl ester is further used to react with a primary or secondary amine to prepare an amide. The two reactions are combined to develop an amide bond and peptide bond formation method that directly use carboxylic acids...