US Patent Issued to JASAN BIO MEDICINE (JIAXING) on May 12 for "Siderophore-dihydrofolate reductase inhibitor conjugate and application thereof" (Chinese Inventors)

ALEXANDRIA, Va., May 12 -- United States Patent no. 12,622,974, issued on May 12, was assigned to JASAN BIO MEDICINE (JIAXING) Co. LTD (Jiaxing, China).

"Siderophore-dihydrofolate reductase inhibitor conjugate and application thereof" was invented by Yun He (Jiaxing, China) and Yan Guan (Jiaxing, China).

According to the abstract* released by the U.S. Patent & Trademark Office: "A conjugate provided. The conjugate is a compound represented by Formula (I), or the conjugate is a stereoisomer, tautomer, homologue, solvate, metabolite, pharmaceutically acceptable salt, or prodrug of the compound represented by Formula (I): where A is a linker, and B is a dihydrofolate reductase inhibitor; R1, R2, R3, R4, and R5 are independently selected from...