US Patent Issued to Istituto Europeo di Oncologia, Universita degli Studi Di Milano on March 17 for "Combinational therapy of LSD1 inhibitors with P21 activators in the treatment of cancer" (Italian Inventors)

ALEXANDRIA, Va., March 17 -- United States Patent no. 12,576,083, issued on March 17, was assigned to Istituto Europeo di Oncologia S.r.l. (Milan) and Universita degli Studi Di Milano (Milan).

"Combinational therapy of LSD1 inhibitors with P21 activators in the treatment of cancer" was invented by Saverio Minucci (Milan), Pier Giuseppe Pelicci (Milan) and Seyed Amir Hosseini (Milan).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are compositions and methods of treating cancer with combinations of cell cycle inhibitors and LSD1 inhibitors. In some aspects, the cell cycle inhibitor is a CDK4/6 inhibitor, e.g., palbociclib. In some aspects, the LSD1 inhibitor is MC2580 or DDP38003. The compositio...